Backed by the Evidence — Not Borrowed Claims.

Vital360Rx is built on the body of research evaluating how nutrition affects strength, treatment tolerance, and recovery in adults with cancer. We’ve synthesized 41 studies into a single review you can read or download.

What we reviewed

41 studies including ESPEN and ASCO guidelines, randomized controlled trials, systematic reviews, and meta-analyses
Four intervention categories: protein-based oral nutrition, structured nutritional counselling, adjunctive nutrients (glutamine, probiotics, HMB, zinc, selenium, vitamin D, magnesium, digestive enzymes), and phytochemical anti-inflammatory agents (curcumin, quercetin, bromelain, boswellic acids, proanthocyanidins)
Outcome focus: treatment tolerance, nutritional status, body composition, muscle strength, quality of life, mucositis, GI toxicity, hospitalization, and inflammatory burden

Key findings (in plain language)

Protein-based oral nutrition consistently helps

A 2025 meta-analysis of 29 RCTs (n=2,279) found high-protein oral nutritional supplements significantly reduced complications by 101 per 1,000 patients and shortened hospital length of stay across multiple cancer types.

Muscle strength can be supported

A 2024 meta-analysis of high-protein supplementation during cancer therapy showed consistent improvements in muscle strength and decreased hospitalization rates.

Vitamin D matters

A 2023 individual patient data meta-analysis found a 12% reduction in cancer mortality with daily vitamin D3 supplementation; a 2024 umbrella review of 71 systematic reviews supported a 10% reduction in total cancer mortality.

Curcumin reduces inflammation and improves quality of life

A 2024 review of 34 RCTs (n=2,580) showed curcumin supplementation reduced inflammatory biomarkers and improved mucositis-related outcomes.

Mucositis interventions work

Multiple meta-analyses support glutamine and zinc for reducing oral mucositis incidence and severity — important because mucositis is one of the leading reasons patients can’t eat enough during treatment.

A multimodal approach makes mechanistic sense

Different ingredients address different pieces of the same problem: protein for muscle, anti-inflammatories for systemic burden, mucosal-support nutrients for intake, and micronutrients for stability.

What the evidence does NOT show

We’re committed to keeping our claims tight to the evidence, so it’s worth being clear about what this review does not establish:

It does not show that Vital360Rx itself has been tested in a cancer clinical trial. The evidence base is on the constituent ingredients.
It does not show survival benefit from any single nutritional intervention.
Some interventions (HMB, certain probiotic protocols) have promising but still emerging evidence — we describe them that way.

Download the Full Review

Methods, results by intervention category, discussion, limitations, and complete references — available as a PDF.